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Contributors
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iii-v
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Contents
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vii-x
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Forthcoming Issues
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xi
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Preface
27 February 2012
Malignant glioblastoma is the most common and lethal primary brain tumor, and arguably the most challenging disease entity encountered in the fields of neuro-oncology and neurosurgery. Currently, aver...
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Isaac Yang,
Seunggu J. Han
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xiii
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Note to Readers
Authors John D. Rolston, MD, PhD, Sharanya Arcot Desai, BE, MSc, Nealen G. Laxpati, BS, and Robert E. Gross, MD, PhD would like to acknowledge the support of Steve M. Potter, PhD during the preparatio...
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John D. Rolston
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xv
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Current Surgical Management of Insular Gliomas
23 February 2012
The insula is a functionally and anatomically complex cortical structure that can be affected by both low-grade and high-grade gliomas. This complexity often prevents many neurosurgeons from attemptin...
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Young-Hoon Kim,
Chae-Yong Kim
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199-206
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The Rise and Fall of “Biopsy and Radiate”: A History of Surgical Nihilism in Glioma Treatment
Many neurosurgeons take a nihilistic approach to surgical treatment of gliomas, stating the inability to achieve a cure. Where this idea comes from is somewhat nebulous to most neurosurgeons. A review...
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Seunggu J. Han,
Michael E. Sughrue
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207-214
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The Use of Motor Mapping to Aid Resection of Eloquent Gliomas
01 March 2012
Surgery remains one of the oldest and still most important forms of treatment for patients with glioma. The advantages of surgical resection for glioma must be balanced with the potential of operative...
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Bryan D. Choi,
Ankit I. Mehta,
Kristen A. Batich,
Allan H. Friedman,
John H. Sampson
et al.
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215-225
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Characteristics and Treatment of Seizures in Patients with High-Grade Glioma: A Review
High-grade gliomas (HGGs), including anaplastic astrocytoma and glioblastoma multiforme, are the most common primary brain tumors, and are often associated with seizures. Seizure control is a critical...
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Dario J. Englot,
Mitchel S. Berger,
Edward F. Chang,
Paul A. Garcia
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227-235
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Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT
24 February 2012
The purpose of this article is to update the neurosurgical field on current molecular markers important to glioblastoma biology, treatment, and prognosis. The highlighted biologic markers in this arti...
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Joaquin Q. Camara-Quintana,
Ryan T. Nitta,
Gordon Li
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237-246
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The Role of Adjuvant Radiation Therapy in the Management of High-Grade Gliomas
16 February 2012
The purpose of this article is to update the neurosurgical community on the role of adjuvant radiation therapy in the management of patients with high-grade glioma. This information guides clinicians ...
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Joshua J. Wind,
Richard Young,
Ashima Saini,
Jonathan H. Sherman
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247-258
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Radiation Options for High-Grade Gliomas
01 March 2012
Radiotherapy has become a part of the standard treatment of high-grade gliomas. Studies have shown that high-dose radiation results in more effective tumor control but at the cost of radionecrosis and...
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Benedict Beng Teck Taw,
Alessandra A. Gorgulho,
Michael T. Selch,
Antonio A.F. De Salles
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259-267
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Radiology: Criteria for Determining Response to Treatment and Recurrence of High-Grade Gliomas
20 February 2012
The development of radiologic criteria for the assessment of response to treatment in high-grade gliomas (HGGs) has evolved considerably over the past few decades since the original response criteria ...
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Joshua Lucas,
Gabriel Zada
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269-276
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Pseudoprogression and Treatment Effect
16 February 2012
The standard of care for newly diagnosed malignant glioblastoma entails postoperative radiotherapy and adjuvant chemotherapy with temozolomide. There has been an increase in the incidence of enhancing...
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Arman Jahangiri,
Manish K. Aghi
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277-287
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The Role of BCNU Polymer Wafers (Gliadel) in the Treatment of Malignant Glioma
20 February 2012
The 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; carmustine) polymer wafer (Gliadel) was developed for use in malignant glioma to deliver higher doses of chemotherapy directly to tumor tissue while byp...
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Seema Nagpal
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289-295
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Alternative Chemotherapeutic Agents: Nitrosoureas, Cisplatin, Irinotecan
20 February 2012
Irinotecan, cisplatin, and nitrosoureas have a long history of use in brain tumors, with demonstrated efficacy in the adjuvant treatment of malignant gliomas. In the era of temozolomide with concurren...
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Jose A. Carrillo,
Claudia A. Munoz
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297-306
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Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme
This article provides historical and recent perspectives related to the use of temozolomide for the treatment of glioblastoma multiforme. Temozolomide has quickly become part of the standard of care f...
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Daniel T. Nagasawa,
Frances Chow,
Andrew Yew,
Won Kim,
Nicole Cremer,
Isaac Yang
et al.
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307-322
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Superselective Intra-Arterial Cerebral Infusion of Novel Agents After Blood–Brain Disruption for the Treatment of Recurrent Glioblastoma Multiforme: A Technical Case Series
20 February 2012
Glioblastoma multiforme constitutes the most common primary brain tumor and carries a grim prognosis for patients treated with conventional therapy including surgery, radiation therapy, and chemothera...
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Benjamin J. Shin,
Jan-Karl Burkhardt,
Howard A. Riina,
John A. Boockvar
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323-329
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The Role of Avastin in the Management of Recurrent Glioblastoma
27 February 2012
Glioblastoma multiforme is a malignant primary brain tumor for which no cure has been developed. However, with aggressive surgical resection, radiation, and the advent of temozolomide, the overall sur...
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Jennifer A. Sweet,
Michelle L. Feinberg,
Jonathan H. Sherman
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331-341
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Management of Multifocal and Multicentric Gliomas
The diffuse nature of gliomas has long confounded attempts at achieving a definitive cure. The advent of computed tomography and magnetic resonance imaging made it increasingly apparent that gliomas c...
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Chirag G. Patil,
Paula Eboli,
Jethro Hu
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343-350
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Index
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351-355
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