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Review Article| Volume 25, ISSUE 1, P137-145, January 2014

Limbic Neuromodulation

Implications for Addiction, Posttraumatic Stress Disorder, and Memory
Published:October 14, 2013DOI:https://doi.org/10.1016/j.nec.2013.08.004

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      References

        • McGinnis J.M.
        • Foege W.H.
        Actual causes of death in the United States.
        JAMA. 1993; 270: 2207-2212
        • Xu F.
        • et al.
        Surveillance for certain health behaviors among States and selected local areas—United States, 2010.
        MMWR Surveill Summ. 2013; 62: 1-247
        • Carelli R.M.
        Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. ‘natural’ reinforcement.
        Physiol Behav. 2002; 76: 379-387
        • Carelli R.M.
        The nucleus accumbens and reward: neurophysiological investigations in behaving animals.
        Behav Cogn Neurosci Rev. 2002; 1: 281-296
        • Gao G.
        • et al.
        Clinical study for alleviating opiate drug psychological dependence by a method of ablating the nucleus accumbens with stereotactic surgery.
        Stereotact Funct Neurosurg. 2003; 81: 96-104
        • Wu H.M.
        • et al.
        Preliminary findings in ablating the nucleus accumbens using stereotactic surgery for alleviating psychological dependence on alcohol.
        Neurosci Lett. 2010; 473: 77-81
        • Müller U.J.
        • et al.
        Deep brain stimulation of the nucleus accumbens for the treatment of addiction.
        Ann N Y Acad Sci. 2013; 1282: 119-128
        • Zahm D.S.
        Functional-anatomical implications of the nucleus accumbens core and shell subterritories.
        Ann N Y Acad Sci. 1999; 877: 113-128
        • Bari A.A.
        • Pierce R.C.
        D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement.
        Neuroscience. 2005; 135: 959-968
        • Wise R.A.
        Addictive drugs and brain stimulation reward.
        Annu Rev Neurosci. 1996; 19: 319-340
        • Olds J.
        • Milner P.
        Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.
        J Comp Physiol Psychol. 1954; 47: 419-427
        • Coenen V.A.
        • et al.
        Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson's disease.
        Neurosurgery. 2009; 64 ([discussion: 1114–5]): 1106-1114
        • Zahm D.S.
        An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens.
        Neurosci Biobehav Rev. 2000; 24: 85-105
        • Lipsman N.
        • Neimat J.S.
        • Lozano A.M.
        Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: the search for a valid target.
        Neurosurgery. 2007; 61 ([discussion: 11–3]): 1-11
        • Foltz E.L.
        • White L.E.
        Pain ‘relief’ by frontal cingulumotomy.
        J Neurosurg. 1962; 19: 89-100
        • Kanaka T.S.
        • Balasubramaniam V.
        Stereotactic cingulumotomy for drug addiction.
        Appl Neurophysiol. 1978; 41: 86-92
        • Balasubramaniam V.
        • Kanaka T.S.
        • Ramanujam P.B.
        Stereotaxic cingulumotomy for drug addiction.
        Neurol India. 1973; 21: 63-66
        • Medvedev S.V.
        • Anichkov A.D.
        • Poliakov I.I.
        Physiological mechanisms of the effectiveness of bilateral stereotactic cingulotomy in treatment of strong psychological dependence in drug addiction.
        Fiziol Cheloveka. 2003; 29 ([in Russian]): 117-123
        • Knight G.
        Chronic depression and drug addiction treated by stereotactic surgery.
        Nurs Times. 1969; 65: 583-586
        • Müller D.
        • Roeder F.
        • Orthner H.
        Further results of stereotaxis in the human hypothalamus in sexual deviations. First use of this operation in addiction to drugs.
        Neurochirurgia (Stuttg). 1973; 16: 113-126
        • Langevin J.P.
        The amygdala as a target for behavior surgery.
        Surg Neurol Int. 2011; 2: 7
        • Lu L.
        • Wang X.
        • Kosten T.R.
        Stereotactic neurosurgical treatment of drug addiction.
        Am J Drug Alcohol Abuse. 2009; 35: 391-393
        • Stelten B.M.
        • Noblesse L.H.
        • Ackermans L.
        • et al.
        The neurosurgical treatment of addiction.
        Neurosurg Focus. 2008; 25: E5
        • Pelloux Y.
        • Baunez C.
        Deep brain stimulation for addiction: why the subthalamic nucleus should be favored.
        Curr Opin Neurobiol. 2013; https://doi.org/10.1016/j.conb.2013.02.016
        • Witjas T.
        • et al.
        Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation.
        Mov Disord. 2005; 20: 1052-1055
        • Rouaud T.
        • et al.
        Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation.
        Proc Natl Acad Sci U S A. 2010; 107: 1196-1200
        • Whiting D.M.
        • et al.
        Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.
        J Neurosurg. 2013; 119: 56-63
        • Volkow N.D.
        • Wise R.A.
        How can drug addiction help us understand obesity?.
        Nat Neurosci. 2005; 8: 555-560
        • Langevin J.P.
        The amygdala as a target for behavior surgery.
        Surg Neurol Int. 2012; 3: 40-46
        • Friedman A.
        • et al.
        Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior.
        Neuropharmacology. 2010; 59: 452-459
        • Hamani C.
        • Temel Y.
        Deep brain stimulation for psychiatric disease: contributions and validity of animal models.
        Sci Transl Med. 2012; 4: 142
        • Stephen J.H.
        • et al.
        Deep brain stimulation compared with methadone maintenance for the treatment of heroin dependence: a threshold and cost-effectiveness analysis.
        Addiction. 2012; 107: 624-634
        • Carter A.
        • Hall W.
        Proposals to trial deep brain stimulation to treat addiction are premature.
        Addiction. 2011; 106: 235-237
        • Luigjes J.
        • et al.
        Deep brain stimulation in addiction: a review of potential brain targets.
        Mol Psychiatry. 2012; 17: 572-583
        • Novakovic V.
        • et al.
        Brain stimulation in posttraumatic stress disorder.
        Eur J Psychotraumatol. 2011; : 2
        • Kessler R.C.
        • et al.
        Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.
        Arch Gen Psychiatry. 2005; 62: 593-602
        • Kessler R.C.
        • Chiu W.T.
        • Demler O.
        • et al.
        Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.
        Arch Gen Psychiatry. 2005; 62: 617-627
        • Breslau N.
        Outcomes of posttraumatic stress disorder.
        J Clin Psychiatry. 2001; 62: 55-59
        • Protopopescu X.
        • et al.
        Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects.
        Biol Psychiatry. 2005; 57: 464-473
        • Semple W.E.
        • et al.
        Higher brain blood flow at amygdala and lower frontal cortex blood flow in PTSD patients with comorbid cocaine and alcohol abuse compared with normals.
        Psychiatry. 2000; 63: 65-74
        • Shin L.M.
        • et al.
        Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD.
        Arch Gen Psychiatry. 2004; 61: 168-176
        • Shin L.M.
        • et al.
        A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.
        Arch Gen Psychiatry. 2005; 62: 273-281
        • Etkin A.
        • Wager T.D.
        Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.
        Am J Psychiatry. 2007; 164: 1476-1488
        • Armony J.L.
        • Corbo V.
        • Clément M.H.
        • et al.
        Amygdala response in patients with acute PTSD to masked and unmasked emotional facial expressions.
        Am J Psychiatry. 2005; 162: 1961-1963
        • Koenigs M.
        • et al.
        Focal brain damage protects against post-traumatic stress disorder in combat veterans.
        Nat Neurosci. 2008; 11: 232-237
        • Koenigs M.
        • Grafman J.
        Posttraumatic stress disorder: the role of medial prefrontal cortex and amygdala.
        Neuroscientist. 2009; 15: 540-548
        • Langevin J.P.
        • De Salles A.A.
        • Kosoyan H.P.
        • et al.
        Deep brain stimulation of the amygdala alleviates post-traumatic stress disorder symptoms in a rat model.
        J Psychiatr Res. 2010; 44: 1241-1245
        • Stidd D.A.
        • Vogelsang K.
        • Krahl S.E.
        • et al.
        Amygdala deep brain stimulation is superior to paroxetine treatment in a rat model of posttraumatic stress disorder.
        Brain Stimul. 2013; https://doi.org/10.1016/j.brs.2013.05.008
        • George M.S.
        • et al.
        A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders.
        Brain Stimul. 2008; 1: 112-121
        • Laakso M.P.
        • et al.
        Hippocampal volumes in Alzheimer‘s disease, Parkinson’s disease with and without dementia, and in vascular dementia: an MRI study.
        Neurology. 1996; 46: 678-681
        • Junqué C.
        • et al.
        Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia.
        Mov Disord. 2005; 20: 540-544
        • Aybek S.
        • et al.
        Hippocampal atrophy predicts conversion to dementia after STN-DBS in Parkinson's disease.
        Parkinsonism Relat Disord. 2009; 15: 521-524
        • Oh Y.S.
        • et al.
        Cognitive improvement after long-term electrical stimulation of bilateral anterior thalamic nucleus in refractory epilepsy patients.
        Seizure. 2012; 21: 183-187
        • Toda H.
        • Hamani C.
        • Fawcett A.P.
        • et al.
        The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation.
        J Neurosurg. 2008; 108: 132-138
        • Arrieta-Cruz I.
        • Pavlides C.
        • Pasinetti G.M.
        Deep brain stimulation in midline thalamic region facilitates synaptic transmission and short-term memory in a mouse model of Alzheimer's disease.
        Transl Neurosci. 2010; 1: 188-194
        • Stone S.S.
        • et al.
        Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory.
        J Neurosci. 2011; 31: 13469-13484
        • Hescham S.
        • et al.
        Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: the role of stimulation parameters.
        Brain Stimul. 2013; 6: 72-77
        • Hamani C.
        • et al.
        Memory enhancement induced by hypothalamic/fornix deep brain stimulation.
        Ann Neurol. 2008; 63: 119-123
        • Laxton A.W.
        • et al.
        A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease.
        Ann Neurol. 2010; 68: 521-534
        • Fontaine D.
        • et al.
        Symptomatic treatment of memory decline in Alzheimer's disease by deep brain stimulation: a feasibility study.
        J Alzheimers Dis. 2013; 34: 315-323
        • Suthana N.
        • et al.
        Memory enhancement and deep-brain stimulation of the entorhinal area.
        N Engl J Med. 2012; 366: 502-510
        • Freund H.J.
        • et al.
        Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
        Arch Neurol. 2009; 66: 781-785
        • Hardenacke K.
        • et al.
        Stimulate or degenerate: deep brain stimulation of the nucleus basalis Meynert in Alzheimer dementia.
        World Neurosurg. 2012; ([Epub ahead of print])
        • Costa A.
        • et al.
        Effects of deep brain stimulation of the pedunculopontine area on working memory tasks in patients with Parkinson's disease.
        Parkinsonism Relat Disord. 2010; 16: 64-67
        • Hu R.
        • Eskandar E.
        • Williams Z.
        Role of deep brain stimulation in modulating memory formation and recall.
        Neurosurg Focus. 2009; 27: E3